The state of the cytokine profile in pregnant women with non-alcoholic fatty liver disease at the stage of non-alcoholic steatohepatitis with varying degrees of comorbid obesity under the influence of the developed complex therapy program

The aim of the study: to evaluate cytokine profile state in pregnant women with non-alcoholic fatty liver disease (NAFLD) at stage steatohepatitis (NASH) varying degrees obesity under influence developed complex therapy program. Material and methods. We examined 197 NAFLD NASH combination obesity. main group I consisted 98 obesity, who were divided into 3 subgroups depending on body mass index (BMI). Among them, 26 BMI 25.0–29.9 kg/m2 included IA group, 48 30.0–34.9 IB 24 35.0–39.9 – IC group. All prescribed including vitamin E a dose 400 IU/day, ursodeoxycholic acid (UDCA) 15 mg/kg/day, L-carnitine g per day. comparison 69 abdominal corresponded (IIA 23 patients, IIB 25 women, IIC 21 women) received basic therapy. control 30 healthy women. To profile, levels IL-1β, IL-6, IL-10 TNF-α determined by ELISPOT. Results. Analysis showed presence systemic inflammation links groups, which was manifested increased pro-inflammatory decreased anti-inflammatory interleukins blood serum A prescription treatment contributed activity inflammatory response, an improvement indicators. Conclusions. during pregnancy is accompanied significant changes profile. form E, UDCA effective due cumulative potentiating effects, reducing manifestations normalizing level cytokines.